TUMORIGENICITY AND IMMUNOGENICITY IN A MURINE MODEL OF B-CELL LEUKEMIA LYMPHOMA (BCL1)/

Multiple injections of intact irradiated BCL1 cells, a murine B-cell l eukemia/lymphoma can trigger a dose-dependent anti-tumor immune respon se in naive syngeneic mice. The ability to induce anti-BCL1 immunity a nd the effect of various cell-modifications on BCL1 tumorigenicity and immunogenicity was evaluated. Newcastle disease virus (NDV) infection dr transfer of cytokine genes by both retroviral and Adeno 5 vectors affect neither tumorigenicity nor immunogenicity of BCL1 cells given a s a non-immunogenic cell-dose. New ways will have to be developed to e licit a reliable and reproducible anti-tumor effect in spontaneously a rising and non-immunogenic hematological malignancies. (C) 1998 Elsevi er Science Ltd. All rights reserved.