CLONAZEPAM RELEASE FROM POLY(DL-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES PREPARED BY DIALYSIS METHOD

Aim of this work is to prepare poly(DL-lactide-co-glycolide) (PLGA) na noparticles by dialysis method without surfactant and to investigate d rug loading capacity and drug release. The size of PLGA nanoparticles was 269.9 +/- 118.7 nm in intensity average and the morphology of PLGA nanoparticles was spherical shape from the observation of SEM and TEM . In the effect of drug loading contents on the particle size distribu tion, PLGA nanoparticles were monomodal pattern with narrow size distr ibution in the empty and lower drug loading nanoparticles whereas bi- or trimodal pattern was showed in the higher drug loading ones. Releas e oi clonazepam from PLGA nanoparticles with higher drug loading conte nts was slower than that with lower loading contents.