Objective: We describe a patient in whom a manic episode was precipita
ted by use of panadeine forte, a preparation containing codeine and pa
racetamol. Clinical picture: The patient developed a discrete manic ps
ychotic episode. Treatment: The treatment consisted of cessation of th
e Panadeine forte and antipsychotic medication. Outcome: The patient m
ade a complete recovery after 1 week. Conclusions: Mania can be induce
d by large doses of Panadeine forte, particularly if there is a biolog
ical predisposition.