HOW (NO) COPPER CAUSES DISEASE

Authors
SOLIOZ M BISSIG KD
Citation
M. Solioz et Kd. Bissig, HOW (NO) COPPER CAUSES DISEASE, Schweizerische medizinische Wochenschrift, 128(31-32), 1998, pp. 1175-1180
Citations number
22
Categorie Soggetti
Medicine, General & Internal
Journal title
Schweizerische medizinische Wochenschrift → ACNP
ISSN journal
00367672
Volume
128
Issue
31-32
Year of publication
1998
Pages
1175 - 1180
Database
ISI
SICI code
0036-7672(1998)128:31-32<1175:H(CCD>2.0.ZU;2-U
Abstract
Copper is an essential cofactor in all cells. However, it remains larg ely unknown how cells deal with this element, which is essential yet t oxic. Through the study of microbial model systems on the one hand, an d the investigation of inherited diseases in copper metabolism on the other, important insights into the way cells deal with copper can be g ained. Two key new elements of copper metabolism have emerged from the se studies: ATP-driven copper pumps and intracellular copper transport proteins, the copper chaperones.