SYNTHESIS OF NEW -(4-CHLOROPHENYL)PERHYDRO-1,3-DIAZEPINE-2,4-DIONES VIA UREIDOBUTYRIC ACIDS

Synthesis of new -(4-chlorophenyl)perhydro-1,3-diazepine-2,4-diones wa s accomplished starting from 4-amino-3-(4-chlorophenyl)butyric acid (B aclofen). The chemical pathway involved the cyclisation of various 3-( 4-chlorophenyl)-4-ureidobutyric acids. However, none of the new deriva tives retained the anticonvulsant activity of their six-membered ring homologues, belonging to the phenylpyrimidinedione series which we rec ently described.