ASYMMETRIC-SYNTHESIS OF (2R,5R)-2,5-DIAMINOHEXAN-1,6-DIOIC ACID

Authors
BULL SD CHERNEGA AN DAVIES SG MOSS WO PARKIN RM
Citation
Sd. Bull et al., ASYMMETRIC-SYNTHESIS OF (2R,5R)-2,5-DIAMINOHEXAN-1,6-DIOIC ACID, Tetrahedron, 54(35), 1998, pp. 10379-10388
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
35
Year of publication
1998
Pages
10379 - 10388
Database
ISI
SICI code
0040-4020(1998)54:35<10379:AO(A>2.0.ZU;2-9
Abstract
Schollkopf's auxiliary 16 was added to bis-lactim iodide 21 to give 1, 2-bis[(3S,6R)-3,6- hydro-2,5-dimethoxy-3-isopropylpyrazin-6-yl]ethane 22 in 50% d.e. Dimer 22 was separated from its diastereoisomer 23 and deprotected using 6M HCl to afford homochiral (2R,5R)-2,5-diaminohexan -1,6-dioic acid 24. (C) 1998 Elsevier Science Ltd. All rights reserved .