ENANTIOSELECTIVE SYNTHESIS OF ALPHA,ALPHA-DISUBSTITUTED-ALPHA-AMINO ACIDS BY A SEQUENTIAL NUCLEOPHILIC-ADDITION TO NITRILES

Authors
CHARETTE AB MELLON C
Citation
Ab. Charette et C. Mellon, ENANTIOSELECTIVE SYNTHESIS OF ALPHA,ALPHA-DISUBSTITUTED-ALPHA-AMINO ACIDS BY A SEQUENTIAL NUCLEOPHILIC-ADDITION TO NITRILES, Tetrahedron, 54(35), 1998, pp. 10525-10535
Citations number
41
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
35
Year of publication
1998
Pages
10525 - 10535
Database
ISI
SICI code
0040-4020(1998)54:35<10525:ESOAA>2.0.ZU;2-K
Abstract
The sequential addition of two different nucleophiles to a tartaric ac id-derived nitrile produced carbinamines. The adducts from chelation-c ontrolled addition which are obtained in high diastereoselectivities a nd yields, were easily converted to alpha,alpha-disubstituted-alpha-am ino acids. (C) 1998 Elsevier Science Ltd. All rights reserved.