ASYMMETRIC NITROGEN - 81 - DIASTEREOMERIC DERIVATIVES OF 1-ALKOXY-2,2-BIS(TRIFLUOROMETHYL)AZIRIDINES - STRUCTURE AND ABSOLUTE-CONFIGURATION

The H-1 NMR spectra of O-derivatives of 1-hydroxy-2,2-bis (trifluorome thyl)aziridine containing such substituents as EtO2CCH2, (R/S)-RO2CCH( Me) (R = Me, Pr-i, or Bu-t), (R/S)-H2NC(O)CH(Me), and (R)-H2NC(O)CH(Me ) were analyzed. Both of the diastereomerically pure amides of the lat ter type were isolated. The validity of the H-1 NMR criteria, which we re suggested for the determination of absolute configurations of diast ereomers of N-alkoxyaziridines, was confirmed by X-ray diffraction stu dy of the (R,R)-amide.