THE SYNTHESIS OF RADIOSENSITIZERS DESIGNED TO BIND TO THE MINOR-GROOVE OF DUPLEX DNA

Authors
PARRICK J PORSSA M JENKINS TC
Citation
J. Parrick et al., THE SYNTHESIS OF RADIOSENSITIZERS DESIGNED TO BIND TO THE MINOR-GROOVE OF DUPLEX DNA, Journal of the Chemical Society. Perkin transactions. I, (22), 1993, pp. 2681-2685
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
22
Year of publication
1993
Pages
2681 - 2685
Database
ISI
SICI code
0300-922X(1993):22<2681:TSORDT>2.0.ZU;2-L
Abstract
The synthesis is described of novel compounds, 17, 21, 25 and 27, cont aining in their molecular architecture both a terminal nitroarene comp onent and an oligopeptide similar to that in the antibiotic distamycin , which is known to bind into the minor groove of duplex DNA. It is ho ped that the compounds may concentrate around DNA in cells and so pote ntiate the action of the nitroarene as a radiosensitizer.