OSTEOFIBROUS-DYSPLASIA-LIKE ADAMANTINOMA OF BONE - A REPORT OF 5 CASES WITH IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES

Citation
G. Kuruvilla et Gc. Steiner, OSTEOFIBROUS-DYSPLASIA-LIKE ADAMANTINOMA OF BONE - A REPORT OF 5 CASES WITH IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES, Human pathology, 29(8), 1998, pp. 809-814
Citations number
19
Categorie Soggetti
Pathology
Journal title
ISSN journal
00468177
Volume
29
Issue
8
Year of publication
1998
Pages
809 - 814
Database
ISI
SICI code
0046-8177(1998)29:8<809:OAOB-A>2.0.ZU;2-8
Abstract
This report describes five cases of osteofibrous dysplasia-like adaman tinoma of the tibia in young patients ranging from ages 4 1/2 to 14 ye ars. Radiologically and histologically these cases were indistinguisha ble from osteofibrous dysplasia of bone, and no epithelial cells; were recognized on routine staining, However, epithelial differentiation w as seen in the form of scattered keratin-positive cells in all five ca ses, and tonofilaments in four cases. The patients were treated by cur ettage, and three had recurrences. Follow-up showed no progression to classic adamantinoma. Osteofibrous dysplasia-like adamantinoma is a sp ecial histological type of adamantinoma that affects children and adol escents. It differs from classic adamantinoma in that it lacks conspic uous nests and masses of epithelial cells, and the prognosis after con servative treatment is generally good. Recent publications suggest tha t osteofibrous dysplasia-like adamantinoma is a precursor of classic a damantinoma, In a comparative study of three cases of classic adamanti noma, we found, in the fibroblastic stroma of the tumors, spindle epit helial cells that were indistinguishable from the epithelial cells of osteofibrous dysplasia-like adamantinoma. This finding suggests that t here is an overlap between these conditions. Four additional cases of osteofibrous dysplasia of the tibia from our files lacked epithelial d ifferentiation. It is most likely that osteofibrous dysplasia is part of the morphologic spectrum of adamantinoma. Copyright (C) 1998 by W.B . Saunders Company.