PERIPHERAL-BLOOD LEVELS OF MATRIX-METALLOPROTEASE-2 AND MATRIX-METALLOPROTEASE-9 ARE ELEVATED IN PATIENTS WITH ACUTE CORONARY SYNDROMES

Objectives. This study was sought to investigate whether peripheral bl ood levels of matrix metalloproteases (MMPs) are affected in patients with acute coronary syndromes (ACS). Background. Synthesis of MMPs has been reported in coronary atherosclerotic lesions in patients with un stable angina (UA), suggesting a pathogenic role of MMPs in the develo pment of ACS. Methods. Using sandwich enzyme immunoassay, serum MMP-2 and plasma MMP-9 were measured in 33 patients with ACS (22 with acute myocardial infarction [AMI], 11 with UA), 17 with stable effort angina (EA) and 17 normal control subjects. Results. Serum MMP-2 in patients with UA and AMI on day 0 was two times greater than that in control s ubjects, and patients with EA showed higher MMP-2 levels than those in control subjects. Plasma MMP-9 in patients with UA and AMI on day 0 w as elevated by threefold and twofold versus that in control subjects, respectively. In patients with UA and AMI who underwent medical treatm ent (n = 11 and 13, respectively), MMP-2 elevation was sustained until day 7. In patients with UA, MMP-9 elevation on day 0 was followed by a gradual decrease toward the control range up to day 7. Some patients with AMI showed a transient MMP-9 elevation with a peak on day 3, whe reas in others, MMP-9 levels were significantly elevated on day 0 and remained higher than those in control subjects up to day 3. Conclusion s. Serial changes in serum MMP-2 and plasma MMP-9 were documented in p atients with ACS. These findings provide an insight into the molecular mechanism of plaque destabilization. (C) 1998 by the American College of Cardiology.