Y. Yamagishi et al., THIAZOHALOSTATIN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY ACTINOMADURA .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 46(11), 1993, pp. 1633-1637
Thiazohalostatin has been isolated from the culture broth of Actinomad
ura sp. by a screening program designed to find novel cytoprotective s
ubstances. It was purified by use of column chromatography on silica g
el, reversed phase HPLC and then isolated as colorless powder. Thiazoh
alostatin prevented cell death caused by calcium overload and exhibite
d an inhibitory activity against lipid peroxidation.