THIAZOHALOSTATIN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY ACTINOMADURA .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES

Authors
YAMAGISHI Y MATSUOKA M ODAGAWA A KATO S SHINDO K MOCHIZUKI J
Citation
Y. Yamagishi et al., THIAZOHALOSTATIN, A NEW CYTOPROTECTIVE SUBSTANCE PRODUCED BY ACTINOMADURA .1. TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 46(11), 1993, pp. 1633-1637
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
11
Year of publication
1993
Pages
1633 - 1637
Database
ISI
SICI code
0021-8820(1993)46:11<1633:TANCSP>2.0.ZU;2-6
Abstract
Thiazohalostatin has been isolated from the culture broth of Actinomad ura sp. by a screening program designed to find novel cytoprotective s ubstances. It was purified by use of column chromatography on silica g el, reversed phase HPLC and then isolated as colorless powder. Thiazoh alostatin prevented cell death caused by calcium overload and exhibite d an inhibitory activity against lipid peroxidation.