AQUASTATIN-A, AN INHIBITOR OF MAMMALIAN ADENOSINE TRIPHOSPHATASES FROM FUSARIUM-AQUAEDUCTUUM - TAXONOMY, FERMENTATION, ISOLATION, STRUCTUREDETERMINATION AND BIOLOGICAL PROPERTIES

Authors
HAMANO K KINOSHITAOKAMI M MINAGAWA K HARUYAMA H KINOSHITA T HOSOYA T FURUYA K KINOSHITA K TABATA K HEMMI A TANZAWA K
Citation
K. Hamano et al., AQUASTATIN-A, AN INHIBITOR OF MAMMALIAN ADENOSINE TRIPHOSPHATASES FROM FUSARIUM-AQUAEDUCTUUM - TAXONOMY, FERMENTATION, ISOLATION, STRUCTUREDETERMINATION AND BIOLOGICAL PROPERTIES, Journal of antibiotics, 46(11), 1993, pp. 1648-1657
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
11
Year of publication
1993
Pages
1648 - 1657
Database
ISI
SICI code
0021-8820(1993)46:11<1648:AAIOMA>2.0.ZU;2-0
Abstract
A new inhibitor of mammalian adenosine triphosphatases, designated aqu astatin A, has been isolated from a fungus identified as Fusarium aqua eductuum. The structure of this compound has been determined by MS and NMR analyses. It inhibits Na+/K+-ATPase with an IC50 value of 7.1 muM , and H+/K+-ATPase with an apparent IC50 value of 6.2 muM.