A NEW ANTIBIOTIC, CYPEMYCIN - TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

Authors
KOMIYAMA K OTOGURO K SEGAWA T SHIOMI K YANG H TAKAHASHI Y HAYASHI M OTANI T OMURA S
Citation
K. Komiyama et al., A NEW ANTIBIOTIC, CYPEMYCIN - TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS, Journal of antibiotics, 46(11), 1993, pp. 1666-1671
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
11
Year of publication
1993
Pages
1666 - 1671
Database
ISI
SICI code
0021-8820(1993)46:11<1666:ANAC-T>2.0.ZU;2-4
Abstract
A new peptide antibiotic, cypemycin, with a molecular weight of 2,097 (M + H), was isolated from the culture broth of Streptomyces sp. OH-41 56. The antibiotic possesses cytocidal activity against P388 leukemia cells in vitro at a concentration of 1.3 mug/ml (IC50 values), and the antibiotic showed antimicrobial activities against Micrococcus luteus (MIC, 0.2 mug/ml).