DEPHOSTATIN, A NOVEL PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR PRODUCED BY STREPTOMYCES .2. STRUCTURE DETERMINATION

Authors
KAKEYA H IMOTO M TAKAHASHI Y NAGANAWA H TAKEUCHI T UMEZAWA K
Citation
H. Kakeya et al., DEPHOSTATIN, A NOVEL PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR PRODUCED BY STREPTOMYCES .2. STRUCTURE DETERMINATION, Journal of antibiotics, 46(11), 1993, pp. 1716-1719
Citations number
2
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
46
Issue
11
Year of publication
1993
Pages
1716 - 1719
Database
ISI
SICI code
0021-8820(1993)46:11<1716:DANPIP>2.0.ZU;2-W
Abstract
Dephostatin, a novel tyrosine phosphatase inhibitor, was isolated from the culture broth of Streptomyces sp. MJ742-NF5. The structure was el ucidated to be 2-(N-methyl-N-nitroso)hydroquinone by spectral and chem ical analyses of dephostatin and its derivatives.