DESIGN, SYNTHESIS AND BIOACTIVITY OF NOVEL ALS INHIBITORS (V) - INITIAL MODEL OF THE HERBICIDAL SULFONYLUREAS AND FUSED HETEROCYCLIC SULFONAMIDES BINDING WITH RECEPTOR

By means of the X-ray diffraction method, quantum pharmacology analysi s and quantitative structure-activity relationships (QSAR) analysis, t he structure-activity relationships of the herbicidal sulfonylureas an d fused heterocyclic sulfonamides were systematically studied. The res ults showed that the structure-activity relationships of these two kin ds of herbicides were identical and that the heterocyclic ring and sul fonyl moiety in the molecules were their pharmacophores which likely b ind in the same receptor sites of acetolactate synthase (ALS). Accordi ng to these results, the initial model of these two kinds of herbicide s binding with the receptor was put forward.