DESIGN, SYNTHESIS AND BIOACTIVITY OF NOVEL ALS INHIBITORS (V) - INITIAL MODEL OF THE HERBICIDAL SULFONYLUREAS AND FUSED HETEROCYCLIC SULFONAMIDES BINDING WITH RECEPTOR
Gf. Yang et al., DESIGN, SYNTHESIS AND BIOACTIVITY OF NOVEL ALS INHIBITORS (V) - INITIAL MODEL OF THE HERBICIDAL SULFONYLUREAS AND FUSED HETEROCYCLIC SULFONAMIDES BINDING WITH RECEPTOR, Science in China. Series B, Chemistry, life sciences & earth sciences, 41(4), 1998, pp. 353-360
By means of the X-ray diffraction method, quantum pharmacology analysi
s and quantitative structure-activity relationships (QSAR) analysis, t
he structure-activity relationships of the herbicidal sulfonylureas an
d fused heterocyclic sulfonamides were systematically studied. The res
ults showed that the structure-activity relationships of these two kin
ds of herbicides were identical and that the heterocyclic ring and sul
fonyl moiety in the molecules were their pharmacophores which likely b
ind in the same receptor sites of acetolactate synthase (ALS). Accordi
ng to these results, the initial model of these two kinds of herbicide
s binding with the receptor was put forward.