THE RELATIONSHIP BETWEEN EXTRACORPOREAL CIRCUIT PRIME, ALBUMIN, AND POSTOPERATIVE WEIGHT-GAIN IN CHILDREN

Objectives: This study evaluated postoperative weight gain in children who received albumin Versus crystalloid prime for cardiopulmonary byp ass (CPB). Design: A retrospective case-controlled study. Children who se extracorporeal (EC) circuit prime contained albumin (group 1) were matched with those whose prime contained only crystalloid (group 2) on the basis of age, weight, and surgical repair. Setting: A university- based medical center. Participants: Seventy-six children (newborn to 4 years of age) who underwent CPB for correction of a congenital heart anomaly from 1993 to 1995. Group 1 underwent surgery from October 1994 to September 1995. and group 2 from February 1993 to September 1994. Interventions: None. Measurements and Main Results: Group 1 had less w eight gain on postoperative days (PODs) 1. 2 and 3 compared with group 2 (p = 0.04 on POD 1). Albumin (grams per milliliter) prime and prime volume in milliliters per kilogram were the best predictors of weight gain (p < 0.004), with prime volume being the more important. Childre n who weighed less than 7.5 kg received more prime volume and had grea ter weight gain than children who weighed 7.5 kg or greater on PODs 1, 2, and 3 (p < 0.02). Conclusion: Data suggest that adding albumin to the EC circuit prime and minimizing the prime volume will result in le ss postoperative weight gain. Further prospective study with a larger sample is warranted to determine whether albumin prime offers other cl inical benefits. Copyright (C) 1998 by W.B. Saunders Company.