It is well known that injuries and deaths due to penetrating projectil
es have become a national and an international epidemic in Western soc
iety. The application of biomedical engineering to solve day-to-day pr
oblems has produced considerable advances in safety and mitigation/pre
vention of trauma. The study of penetrating trauma has been largely in
the military domain where war-time specific applications were advance
d with the use of hi,oh-velocity weapons. With the velocity and weapon
caliber in the civilian population at half or less compared with the
military counterpart, wound ballistics is a largely different problem
in today's trauma centers. The principal goal of the study of penetrat
ing injuries in the civilian population is secondary prevention and op
timized emergency care after occurrence. A thorough understanding of t
he dynamic biomechanics of penetrating injuries quantifies missile typ
e, caliber, and velocity to hard and soft tissue damage. Such informat
ion leads to a comprehensive assessment of the acute and long-term tre
atment of patients with penetrating injuries. A review of the relevant
military research applied to the civilian domain and presentation of
new technology in the biomechanical study of these injuries offer foun
dation to this field. Relevant issues addressed in this review article
include introduction of the military literature, the need for seconda
ry prevention, environmental factors including projectile velocity and
design, experimental studies with biological tissues and physical mod
els, and mathematical simulations and analyses, Areas of advancement a
re identified that enables the pursuit of biomechanics research in ord
er to arrive at better secondary prevention strategies.