A 63-year-old woman presented with a single plaque on her left earlobe
that was shown to be a B-cell lymphoma on histopathologic examination
. Immunohistochemical studies on the paraffin-embedded tissue and now
cytometry of fresh tissue helped characterize the neoplasm. She had no
other systemic involvement and a diagnosis of primary cutaneous B-cel
l lymphoma was made. This neoplasm has, in general, a good prognosis w
ith excellent response to radiation therapy, polychemotherapy, or both
.