THE EFFECT OF PHORBOL ESTER TREATMENT ON MIGRATION OF C3H 10T1 2 AND BT5C GLIOMA-CELLS - POSSIBLE APPLICATION TO CARCINOGENESIS/

Authors
JANIK P SZANIAWSKA B KOWALCZYK D MILOSZEWSKA J
Citation
P. Janik et al., THE EFFECT OF PHORBOL ESTER TREATMENT ON MIGRATION OF C3H 10T1 2 AND BT5C GLIOMA-CELLS - POSSIBLE APPLICATION TO CARCINOGENESIS/, Journal of cancer research and clinical oncology, 120(3), 1994, pp. 156-158
Citations number
24
Categorie Soggetti
Oncology
Journal title
Journal of cancer research and clinical oncology → ACNP
ISSN journal
01715216
Volume
120
Issue
3
Year of publication
1994
Pages
156 - 158
Database
ISI
SICI code
0171-5216(1994)120:3<156:TEOPET>2.0.ZU;2-1
Abstract
Treatment with the tumor-promoting phorbol ester 12-O-tetradecanoylpho rbol 13-acetate (TPA) and the second-stage promotor 12-O-retinoylphorb ol 13-acetate induced down-regulation of protein kinase C (PKC) and en hanced the migration of C3H 10T1/2 cells. In the case of BT5C glioma c ells the same negative correlation was observed only after treatment w ith TPA. The negative control 4alpha-phorbol affected neither PKC acti vity nor the migratory ability of both cell lines.