GP80 (CLUSTERIN, TRPM-2) MESSENGER-RNA LEVEL IS ENHANCED IN HUMAN RENAL CLEAR-CELL CARCINOMAS

Authors
PARCZYK K PILARSKY C RACHEL U KOCHBRANDT C
Citation
K. Parczyk et al., GP80 (CLUSTERIN, TRPM-2) MESSENGER-RNA LEVEL IS ENHANCED IN HUMAN RENAL CLEAR-CELL CARCINOMAS, Journal of cancer research and clinical oncology, 120(3), 1994, pp. 186-188
Citations number
21
Categorie Soggetti
Oncology
Journal title
Journal of cancer research and clinical oncology → ACNP
ISSN journal
01715216
Volume
120
Issue
3
Year of publication
1994
Pages
186 - 188
Database
ISI
SICI code
0171-5216(1994)120:3<186:G(TMLI>2.0.ZU;2-6
Abstract
The gp80 glycoprotein complex (clusterin, apolipoprotein J, TRPM-2) is a widely expressed protein that has been attributed functions in tiss ue remodelling, immune defense and transport of lipids and biologicall y active peptides. The expression of the protein appears to be elevate d in several neurodegenerative, apoptotic and malignant processes. We show here that in patients with renal clear cell carcinoma gp80 mRNA i s 3-fold overexpressed in tissue of the tumors compared with adjacent non-tumor tissue.