We assessed the efficacy of emergency percutaneous cardiopulmonary byp
ass support (PCPS) in the treatment of patients with acute myocardial
infarction complicated by cardiogenic shock. Emergency PCPS was instit
uted in 21 consecutive patients beginning in 1991, After the stabiliza
tion of the hemodynamics, coronary reperfusion was performed by means
of coronary artery bypass grafting or percutaneous transluminal corona
ry angioplasty. Of the seven patients with acute myocardial infarction
involving either the left main or two-vessel territories, five surviv
ed more than 1 month, but only one patient remained alive and well aft
er 20 months. The main cause of death for this group was low output sy
ndrome. Four of 12 patients with acute left main trunkal occlusion in
the catheter laboratory survived and showed a preserved cardiac functi
on (mean followup 28.5 months). The main cause of death for this group
was brain damage. Two patients with single-vessel territory acute myo
cardial infarction underwent PCPS to treat refractory ventricular fibr
illation. Both patients were still alive and well at a 12-month follow
up. Percutaneous cardiopulmonary bypass support successfully stabilize
d the hemodynamics, allowing time to perform revascularization for all
three groups of patients with life-threatening acute myocardial infar
ction. Recanalization was nevertheless unable to salvage the damaged m
yocardium in cases of prolonged ischemic time.