HEMOLYTIC REACTION DUE TO GRAFT-VERSUS-HOST (GVH) ANTIBODY-PRODUCTIONAFTER LIVER-TRANSPLANTATION FROM LIVING DONORS - REPORT OF 2 CASES

Among 27 patients who received minor ABO-incompatible partial liver tr ansplantations and 19 who received major ABO-incompatible partial live r transplantations from living donors, 2 developed hemolytic anemia wi thin 2 weeks after transplantation. These 2 patients had received live rs from their living fathers whose blood type was ABO-incompatible. B- to-A transplantation was performed in patient 1 and O-to-B transplanta tion was performed in patient 2. Anti-A IgM and IgG were detected in t he serum of patient 1, and anti-B IgM and IgG were detected in the ser um of patient 2. These antibodies were eluted from the red blood cells of the patients. The coexistence of donor-specific DNA in the periphe ral blood of the patients proved that they had chimerism, and graft-ve rsus-host antibody production due to passenger B lymphocytes in the do nor's liver was subsequently confirmed.