MITOCHONDRIAL LIPID-PEROXIDATION AND ANTIOXIDANT SYSTEM IN AGED RATS

Authors
DOGRUABBASOGLU S UGURNAL B TAMERTOPTANI S AKDENIZ S AYKACTOKER G KOCAKTOKER N UYSAL M
Citation
S. Dogruabbasoglu et al., MITOCHONDRIAL LIPID-PEROXIDATION AND ANTIOXIDANT SYSTEM IN AGED RATS, Archives of gerontology and geriatrics, 27(1), 1998, pp. 35-40
Citations number
25
Categorie Soggetti
Geiatric & Gerontology
Journal title
Archives of gerontology and geriatrics → ACNP
ISSN journal
01674943
Volume
27
Issue
1
Year of publication
1998
Pages
35 - 40
Database
ISI
SICI code
0167-4943(1998)27:1<35:MLAASI>2.0.ZU;2-W
Abstract
Mitochondria are especially important in cellular senescence since rea ctive oxygen species (ROS) have been found to be generated constantly as an endogen threat. On the other hand, mitochondrial defence depends mainly on glutathione (GSH), superoxide dismutase (SOD) and glutathio ne peroxidase (GP(x)). In this study, liver and brain mitochondria of 6- and 22-month-old rats were investigated. Liver mitochondrial malond ialdehyde (MDA) levels were found increased, whereas mitochondrial GSH was decreased. SOD activity has been observed elevated, whereas GP(x) was unchanged. However, brain mitochondrial MDA, GSH and SOD and GP(x ) activites were found unchanged in old rats. (C) 1998 Elsevier Scienc e Ireland Ltd. All rights reserved.