ABERRANT ISOFORM OF VASCULAR ENDOTHELIAL GROWTH-FACTOR-189 EXPRESSIONIS CORRELATED WITH XENOTRANSPLANTABILITY OF HUMAN ESOPHAGEAL CANCER

Authors
TOKUNAGA T KIJIMA H OSHIKA Y FUKUSHIMA Y ABE Y OHNISHI Y YAMAZAKI H TSUCHIDA T MAKUUCHI H TAMAOKI N UEYAMA Y NAKAMURA M
Citation
T. Tokunaga et al., ABERRANT ISOFORM OF VASCULAR ENDOTHELIAL GROWTH-FACTOR-189 EXPRESSIONIS CORRELATED WITH XENOTRANSPLANTABILITY OF HUMAN ESOPHAGEAL CANCER, Oncology Reports, 5(5), 1998, pp. 1115-1118
Citations number
21
Categorie Soggetti
Oncology
Journal title
Oncology Reports → ACNP
ISSN journal
1021335X
Volume
5
Issue
5
Year of publication
1998
Pages
1115 - 1118
Database
ISI
SICI code
1021-335X(1998)5:5<1115:AIOVEG>2.0.ZU;2-J
Abstract
Xenografted neoplastic tissues are often utilized to study biology of human cancer. We studied isoform pattern (VEGF206, VEGF189, VEGF165, V EGF121) of an angiogenic factor VEGF in both esophageal primary cancer s and cancer xenografts by RT-PCR analysis. Eighteen of 19 (95%) xenog rafts showed the cell associated aberrant isoform of VEGF189 at a sign ificantly higher incidence than 19 of 31 (61%) primacy cancers (P=0.00 9, Fisher's exact test). These observations suggested that the aberran t isoform of VEGF189 mRNA affects the xenotransplantability of human e sophageal cancer.