EMBRYONAL DYSMORPHOGENESIS IN FETUSES OF PREGNANT TUMOR-BEARING MICE

The embryolethal and teratogenic effects of Lewis lung carcinoma and E hrlich carcinoma growing against the pregnancy background iwere invest igated in mice. Maternal tumour growth was associated with an increase d incidence of fetal loss, growth retardation, placenta hypoplasia, an d congenital abnormalities. The most common abnormalities were central nervous system defects (exencephalus, hydrocephalus) and dysmorphogen esis of liver and kidney tissues as well as the injury of thin archite cture of the placenta. The primary role of maternal factors in the emb ryonal development regulation is discussed.