CELLULAR INJURY SCORE FOR MULTIPLE ORGAN FAILURE SEVERITY SCORING SYSTEM

Background: Cellular Injury Score (CIS) is an index of cellular injury , being calculated from three parameters of intra cellular metabolism: arterial ketone body ratio, osmolality gap, and blood lactate. Method s: The usefulness of CIS as a severity scoring system for patients wit h multiple organ failure was prospectively evaluated in 157 consecutiv e patients with MOF (58 survivors, 99 nonsurvivors). Results: CISs in nonsurvivors were significantly higher compared with those in survivor s throughout the clinical courses. CIS was significantly correlated wi th the number of failing organs and mortality rate. The optimal cutoff point of CIS from receiver operating characteristics curve analysis w as 4 for the maximal value during the clinical course, The changes in CIS well reflected the severity of injury in survivors and nonsurvivor s who died within 2 weeks. Conclusion: CIS could be a useful index for mortality risk prediction and is potentially applicable as a severity scoring system for individual patients with MOF.