Unlike classical papillary carcinoma, diffuse sclerosing papillary thy
roid carcinoma presents as a diffuse goiter with a discretely irregula
r surface, associated to hypo or hyperthyroidism, specially in young w
omen. We report two women aged 41 and 23 years old with this disease,
one with normal thyroid function and the other with hyperthyroidism. I
t is concluded that diffuse sclerosing papillary thyroid carcinoma mus
t be suspected in patients with rapidly growing goiter with irregular
surface or diffuse minute calcifications, specially in the presence of
hypo or hyperthyroidism. Fine needle aspiration is a good diagnostic
procedure.