MECHANISMS OF PROTEIN SORTING AND COAT ASSEMBLY - INSIGHTS FROM THE CLATHRIN-COATED VESICLE PATHWAY

Clathrin-coated vesicles have provided the best example illustrating h ow both soluble and membrane proteins are selectively clustered into a transport intermediate for subsequent delivery to another intracellul ar compartment. Like cytosolic clathrin adaptors, the adaptor-like com plex AP-3 binds to specific membranes and selects membrane proteins by interacting with their sorting signals.