Dynamin's role in clathrin-mediated endocytosis is now well establishe
d. Here we review new evidence from the past two years for the functio
n of dynamin and related GTPases in other intracellular trafficking ev
ents. We then summarize current information on the domain structure an
d function of this multidomain GTPase. Finally, we describe dynamin pa
rtners and their function in the context of clathrin-mediated endocyto
sis.