A NEW MURINE MODEL FOR MAMMALIAN WOUND REPAIR AND REGENERATION

Citation
Ld. Clark et al., A NEW MURINE MODEL FOR MAMMALIAN WOUND REPAIR AND REGENERATION, Clinical immunology and immunopathology (Print), 88(1), 1998, pp. 35-45
Citations number
34
Categorie Soggetti
Pathology,Immunology
ISSN journal
00901229
Volume
88
Issue
1
Year of publication
1998
Pages
35 - 45
Database
ISI
SICI code
0090-1229(1998)88:1<35:ANMMFM>2.0.ZU;2-Q
Abstract
Regeneration is generally considered to be a phenomenon restricted to amphibians in which amputated limbs reform and regrow. We have recentl y noted a strain of mouse, the MRL, which displays a remarkable capaci ty for cartilagenous wound closure and provides an example of a phenom enon previously considered to be a form of regeneration. Specifically, through-and-through ear punches rapidly attain full closure with norm al tissue architecture reminiscent of regeneration seen in amphibians as opposed to scarring, as usually seen in mammals. Histologically, we have demonstrated normal cell growth and microanatomy, including angi ogenesis and chondrogenesis, as opposed to control C57BL/6 mice which have ear holes that contract minimally but do not close. Finally, this phenomenon is a genetically definable quantitative trait, (C) 1998 Ac ademic Press.