CHARACTERIZATION OF A COLLECTING DUCT CARCINOMA BY CYTOGENETIC ANALYSIS AND COMPARATIVE GENOMIC HYBRIDIZATION

Collecting duct carcinoma (CDC) is a rare variant of carcinoma of the kidney with aggressive behaviour. CDC arise from the epithelium of the ducts of Bellini in the distal nephron. A CDC in a 53-year old male p atient is characterised both by cytogenetic analysis and comparative g enomic hybridisation (CGH). The cytogenetic analysis shows a biclonal karyotype 47,XY,+3[2]/40-44,XY,-12[3],-22[4] [cp5]/46,XY[42]. Loss of DNA sequences detected by CGH involves chromosome 1, 2, 9, 11 and 18. Gain of DNA sequences affect chromosome 16 and 20. The characterisatio n of a CDC in this study represents an additional contribution to the poorly explored CDC.