EFFICACY OF TOPIRAMATE

In controlled clinical trials, topiramate (Topamax(R)) has demonstrate d efficacy in refractory patients with complex partial seizures and se condarily generalized tonic-clonic seizures. Approximately 45 percent of 534 patients had a greater than or equal to 50 percent reduction in seizure frequency. Limited open label trials have shown that topirama te has broad spectrum activity and may be effective in patients with p rimary generalized epilepsies. The efficacy of topiramate compares ver y favourably with the efficacy of other new antiepileptic drugs recent ly introduced.