Epidemiological evidence suggests that 20 to 40% of all patients with
heart failure have normal systolic function. Isolated diastolic dysfun
ction may be the principle pathophysiological mechanism in these patie
nts. The diagnosis of isolated diastolic heart failure is problematic
and not merely based on demonstrating normal systolic function. The pr
ognosis in isolated diastolic heart failure is more favourable than in
systolic heart failure. At the present time, there is no licensed tre
atment for isolated diastolic heart failure and treatment is largely e
mpirical.