ELEVATED GLYCATED HEMOGLOBIN IN NONDIABETIC PATIENTS IS ASSOCIATED WITH AN INCREASED MORTALITY IN MYOCARDIAL-INFARCTION

Diabetes is associated with increased mortality following acute myocar dial infarction compared to the general population. Elevated glycated haemoglobin (HbA(1c)) in diabetic patients is also associated with inc reased mortality following acute myocardial infarction, while mild ele vations in HbA(1c) are associated with impaired glucose tolerance. The aim of this study was to determine the influence of HbA(1c) on outcom e of acute myocardial infarction in 253 non-diabetic patients, 46 of w hom died in one year. In univariate analysis, risk factors for death i ncluded smoking, glucose, cholesterol and HbA(1c). In logistic regress ion analysis HbA(1c) was an independent risk factor for death. Over on e-third of the fatality group had an HbA(1c) in the highest quartile, compared to one-fifth of the surviving group (p=0.02). Elevated HbA(1c ) is a risk marker for shortterm mortality following acute myocardial infarction in non-diabetic subjects.