MODELS OF INTERACTION BETWEEN METABOLIC GENES AND ENVIRONMENTAL EXPOSURE IN CANCER SUSCEPTIBILITY

Citation
E. Taioli et al., MODELS OF INTERACTION BETWEEN METABOLIC GENES AND ENVIRONMENTAL EXPOSURE IN CANCER SUSCEPTIBILITY, Environmental health perspectives, 106(2), 1998, pp. 67-70
Citations number
27
Categorie Soggetti
Public, Environmental & Occupation Heath","Environmental Sciences
ISSN journal
00916765
Volume
106
Issue
2
Year of publication
1998
Pages
67 - 70
Database
ISI
SICI code
0091-6765(1998)106:2<67:MOIBMG>2.0.ZU;2-6
Abstract
Polymorphic metabolic genes that confer enhanced genetic susceptibilit y to the carcinogenic effects of certain environmental carcinogens act according to a type 2 interaction between genetic and environmental r isk factors. This type of interaction, for which the gene has no effec t on disease outcome by itself but only modifies the risk associated w ith exposure, must be treated differently from other types of gene-env ironment interaction.We present a method to analyze different dose eff ects often seen in studies involving these genes. We define a low expo sure-gene effect, when a greater degree of gene environment interactio n appears at lower doses of exposure (the interaction follows an inver se dose function), and a converse high exposure-gene effect, when the interaction increases as a function of dose. Using a standard logistic regression model, we define a new term, ct, that can be determined as a function of exposure dose in order to analyze epidemiological studi es for the type of exposure-gene effect. These models are illustrated by the use of hypothetical case-control data as well as examples from the literature.