THE TRAIL OF DEATH

Citation
Rg. Goodwin et Ca. Smith, THE TRAIL OF DEATH, Apoptosis, 3(2), 1998, pp. 83-88
Citations number
44
Categorie Soggetti
Cell Biology",Biology
Journal title
ISSN journal
13608185
Volume
3
Issue
2
Year of publication
1998
Pages
83 - 88
Database
ISI
SICI code
1360-8185(1998)3:2<83:>2.0.ZU;2-#
Abstract
The TNF ligand family member termed TRAIL has been shown to induce apo ptosis in a wide variety of transformed cell lines. The normal functio ns of this cytokine in vivo remain, however, relatively unknown. The c omplexity of this biological system has now increased unexpectedly wit h the identification of four distinct receptors for TRAIL, two of whic h have cytoplasmic death domains. This review will describe the known biological effects of TRAIL, as well as the structure and possible fun ctions of its recently identified receptors.