GESTATIONAL AGE-DEPENDENT REFERENCE VALUES FOR IRON AND SELECTED PROTEINS OF IRON-METABOLISM IN SERUM OF PREMATURE HUMAN NEONATES

The diagnosis and treatment of fetal and neonatal diseases requires kn owledge of gestational age-dependent reference ranges for most laborat ory values. It was the aim of the present study to establish reference values for serum iron, transferrin, ferritin and ceruloplasmin concen trations in premature neonates, thereby paying attention to the possib le changes with gestational age. Blood samples were taken from 100 pre mature neonates within the first hour of life. Total serum iron, trans ferrin, ferritin and ceruloplasmin concentrations were determined, tra nsferrin saturation was calculated. Newborns who developed a presumed oxygen radical disease of prematurity were excluded from the study (n = 37), because previous investigations could demonstrate significantly lower serum transferrin and ceruloplasmin concentrations in premature s suffering one of these disorders. Related to gestational age, only s erum transferrin concentration showed a statistically significant incr ease and correlation (r = 0.47; p < 0.0001) with rising age. Although statistically not significant, even serum ferritin concentration incre ased with rising age of the neonates. None of the investigated laborat ory values correlated with birth weight. Only ferritin showed a slight , but statistically not significant increase with higher body mass. We conclude that gestational age-dependent changes of serum transferrin levels must be considered in the judgement of fetal and neonatal disea ses, whereas total serum iron and ceruloplasmin concentrations remain rather constant at least during the last weeks of gestation.