GENE IDENTIFICATION IN ASTHMA AND ALLERGY

Asthma and atopy are due to the interaction between genetic and enviro nmental factors. The genetic basis of asthma and atopy is becoming mor e certain, with the promise of improvements in the diagnosis and treat ment of these disorders. A combination of candidate gene and positiona l cloning studies has already identified several genes which influence allergic disease. These genes predispose in general to atopy, or infl uence the specific IgE response to individual allergens, or enhance in flammation independently of atopic mechanisms. In addition to these kn own factors, the chromosomal localisation of other putative genes is b ecoming clear.