SPECIFIC TOLERANCE INDUCTION AND ORGAN-TRANSPLANTATION

Citation
A. Devriesvanderzwan et al., SPECIFIC TOLERANCE INDUCTION AND ORGAN-TRANSPLANTATION, Leukemia & lymphoma, 31(1-2), 1998, pp. 131-142
Citations number
55
Categorie Soggetti
Hematology,Oncology
Journal title
ISSN journal
10428194
Volume
31
Issue
1-2
Year of publication
1998
Pages
131 - 142
Database
ISI
SICI code
1042-8194(1998)31:1-2<131:STIAO>2.0.ZU;2-Q
Abstract
Induction of tolerance to histocompatibility antigens of an organ dono r would eliminate the need for long-term administration of nonspecific immunosuppressive drugs associated with an increased risk of infectio n and malignancies. Recently, we established a murine model in which r ecipient mice were treated with a single dose of anti-CD3, anti-CD4, l ow dose of total body irradiation (TBI) and allogeneic bone marrow cel ls. Our results clearly demonstrate that stable multilineage mixed chi merism, immunocompetence and permanent donor-specific skin graft toler ance across full major histocompatibility (MHC) barriers can be succes sfully achieved in this way.:The observations that the preparative reg imen and skin transplantation can be performed on the same day, and th at a significant reduction in irradiation dose is sufficient in haploi dentical donor-recipient combinations (MHC-sharing effect), bring our protocol closer to clinical use.