INDIVIDUAL ALLERGENS AS RISK-FACTORS FOR BRONCHIAL RESPONSIVENESS IN YOUNG-ADULTS

Background-Bronchial responsiveness is known to be related to atopy, b ut the relative contribution of sensitisation to individual allergens in the UK, or whether serum total IgE is an independent risk factor, i s unknown. Methods-A random sample of 1864 men and women aged 20-44 ye ars, drawn from family health service registers in Cambridge, Ipswich and Norwich, was invited to answer a detailed questionnaire, undergo s kin prick tests and methacholine bronchial challenge, and provide a se rum sample for measurement of total and specific IgE. The relation of bronchial responsiveness to risk factors was studied in 749 subjects ( 40.2%) with complete data. Results-Bronchial responsiveness was increa sed in those sensitised to cat, D pteronyssinus, Timothy grass and Cla dosporium, but decreased in subjects also positive to birch allergen. Additional skin prick tests added little information. Serum total IgE was not significantly related after adjustment for specific IgE to the five allergens. Increasing titres of specific IgE to D pteronyssinus were associated with increasing bronchial responsiveness. Specific IgE to Cladosporium had a prevalence of around 3%, but was associated wit h greatly increased responsiveness. Decreased baseline lung function w as related (p<0.001) to increased responsiveness. There was an interac tion between age and smoking status, with lower responsiveness in olde r non-smokers. Conclusion-Atopy is the most important risk factor for bronchial responsiveness in this age group, but effects are not additi ve across all allergens. Research in reducing exposure to house dust m ite should also address the role of Cladosporium sensitisation and exp osure to indoor moulds.