SCREENING OF AMYLOID PRECURSOR PROTEIN GENE MUTATION (APP717VAL-]ILE)IN SWEDISH FAMILIES WITH ALZHEIMERS-DISEASE

Screening for the APP 717 Val --> Ile mutation in the amyloid precurso r protein (APP) gene in 34 Swedish families with familial Alzheimer's disease (FAD), 16 sporadic cases of Alzheimer's disease and five patie nts with Down's syndrome (DS) failed to identify further cases of the mutation. These results suggests that the mutation is rare among Swedi sh families with Alzheimer's disease. In addition, we summarize presen t reports of the frequency of the mutation.