IN-VITRO STUDIES ON THE METABOLISM OF ANTIPYRINE IN THE PIG AND RAT -WITH SPECIAL REFERENCE TO VETERINARY-MEDICINE LICENSING

Preparation of product licence applications for veterinary medicines r equires metabolic studies in the target species. This experimental pro cedure uses animals and Is costly. In the present report of preliminar y studies it is demonstrated that pig liver homogenates prepared from abattoir material and homogenates of rat liver show the interspecies m etabolic differences that would be expected in vivo. The results there fore support the use of abattoir-derived liver homogenates in prelimin ary studies to investigate target species metabolism in veterinary dru g development.