BLOCKADE BY NICKEL IONS OF PHASIC CONTRACTION TO K-AFFINITY CALCIUM OF ILEAL LONGITUDINAL MUSCLE OF GUINEA-PIG( AND HIGH)

Authors
NASU T YAMAGUCHI K SHIBATA H
Citation
T. Nasu et al., BLOCKADE BY NICKEL IONS OF PHASIC CONTRACTION TO K-AFFINITY CALCIUM OF ILEAL LONGITUDINAL MUSCLE OF GUINEA-PIG( AND HIGH), Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 106(2), 1993, pp. 377-381
Citations number
10
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology → ACNP
ISSN journal
07428413
Volume
106
Issue
2
Year of publication
1993
Pages
377 - 381
Database
ISI
SICI code
0742-8413(1993)106:2<377:BBNIOP>2.0.ZU;2-A
Abstract
1. Preincubation with 1 or 2 mM Ni2+ inhibited dose-dependently the il eal phasic response to K+ (60 mM) without appreciable effects on the t onic response. Ni2+ above 3 mM inhibited the tonic response. 2. Ni2+ i nhibited the high affinity Ca2+ sites than the low affinity sites duri ng K+ contraction. 3. After treatment with Ni2+, the K+ response was f airly restored by a wash with normal medium. The nickel bound to the i leal cells was almost eliminated with the washing. 4. This probably in dicates that Ni2+ mainly inhibited the K+-induced phasic tension by re ducing Ca2+ release rather than Ca2+ influx.