EFFECT OF A SHORT-TERM CAPTOPRIL TREATMENT ON SERUM AND TISSUE ANGIOTENSIN I-CONVERTING ENZYME-ACTIVITY FROM 4 MAMMALIAN-SPECIES - DIFFERENCES USING DIAMIDE IN THE IN-VITRO ASSAY

Authors
IBARRARUBIO ME MEDINACAMPOS ON CRUZ C PEDRAZACHAVERRI J
Citation
Me. Ibarrarubio et al., EFFECT OF A SHORT-TERM CAPTOPRIL TREATMENT ON SERUM AND TISSUE ANGIOTENSIN I-CONVERTING ENZYME-ACTIVITY FROM 4 MAMMALIAN-SPECIES - DIFFERENCES USING DIAMIDE IN THE IN-VITRO ASSAY, Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 106(2), 1993, pp. 395-401
Citations number
40
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology → ACNP
ISSN journal
07428413
Volume
106
Issue
2
Year of publication
1993
Pages
395 - 401
Database
ISI
SICI code
0742-8413(1993)106:2<395:EOASCT>2.0.ZU;2-L
Abstract
1. Angiotensin I-converting enzyme (ACE) activity was determined in se rum and nine tissues from control and captopril-treated rats, mice, gu inea pigs and rabbits. 2. ACE activity was determined with and without sample pretreatment with diamide (total and basal activity, respectiv ely). 3. A very different pattern of response to captopril was observe d among the different species. 4. There was no relationship between se rum ACE activity and the response to captopril. 5. There were importan t differences in the determinations of total or basal ACE activities. 6. Endogenous ACE inhibitors were found in some tissues from mouse and rabbit.