RENAL-CELL CANCER CORRELATED WITH OCCUPATIONAL EXPOSURE TO TRICHLOROETHENE

A previous cohort-study in a cardboard factory demonstrated that high and prolonged occupational exposure to trichloroethene (C2HCl3) is ass ociated with an increased incidence of renal cell cancer. The present hospital-based case/control study investigates occupational exposure i n 58 patients with renal cell cancer with special emphasis on C2HCl3 a nd the structurally and toxicologically closely related compound tetra chloroethene (C2Cl4) A group of 84 patients from the accident wards of three general hospitals in the same area served as controls. Of the 5 8 cases, 19 had histories of occupational C2HCl3 exposure for at least 2 years and none had been exposed to C2Cl4; Of the 84 controls, 5 had been occupationally exposed to C2HCl3 and 2 to C2Cl4 After adjustment for other risk factors, such as age, obesity, high blood pressure, sm oking and chronic intake of diuretics, the study demonstrates an assoc iation of renal cell cancer with long-term exposure to C2HCl3 (odds ra tio 10.80; 95% CI: 3.36-34.75).