S. Ebong et Wr. Farkas, ABSENCE OF PLASMA AMINE OXIDASE IN SOME FREQUENTLY USED ANIMAL-MODELS, Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 106(2), 1993, pp. 483-487
1. Plasma amine oxidase (PAO), an enzyme that oxidizes primary amines
is generally assumed to be present in the sera of all mammals. 2. We s
tudied plasma from eleven different mammals to determine if they could
oxidize a group of amines of biomedical interests. 3. Our results ind
icate that PAO is not present in all mammals and also that substrate s
pecificity of the enzyme varies within the species tested. Rodents whi
ch are frequently used as animal models in pharmacology and toxicology
do not contain PAO. 4. The common polyamines, spermine, spermidine an
d putrecine were oxidized only by bovine plasma.