ABSENCE OF PLASMA AMINE OXIDASE IN SOME FREQUENTLY USED ANIMAL-MODELS

Authors
EBONG S FARKAS WR
Citation
S. Ebong et Wr. Farkas, ABSENCE OF PLASMA AMINE OXIDASE IN SOME FREQUENTLY USED ANIMAL-MODELS, Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 106(2), 1993, pp. 483-487
Citations number
11
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology → ACNP
ISSN journal
07428413
Volume
106
Issue
2
Year of publication
1993
Pages
483 - 487
Database
ISI
SICI code
0742-8413(1993)106:2<483:AOPAOI>2.0.ZU;2-F
Abstract
1. Plasma amine oxidase (PAO), an enzyme that oxidizes primary amines is generally assumed to be present in the sera of all mammals. 2. We s tudied plasma from eleven different mammals to determine if they could oxidize a group of amines of biomedical interests. 3. Our results ind icate that PAO is not present in all mammals and also that substrate s pecificity of the enzyme varies within the species tested. Rodents whi ch are frequently used as animal models in pharmacology and toxicology do not contain PAO. 4. The common polyamines, spermine, spermidine an d putrecine were oxidized only by bovine plasma.