EFFECT OF CHLORIDE AND DIAMIDE ON SERUM ANGIOTENSIN I-CONVERTING ENZYME-ACTIVITY FROM 8 MAMMALIAN-SPECIES

Authors
IBARRARUBIO ME GOMEZVELEZ LA CRUZ C PEDRAZACHAVERRI J
Citation
Me. Ibarrarubio et al., EFFECT OF CHLORIDE AND DIAMIDE ON SERUM ANGIOTENSIN I-CONVERTING ENZYME-ACTIVITY FROM 8 MAMMALIAN-SPECIES, Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology, 106(2), 1993, pp. 495-501
Citations number
26
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. C. Comparative pharmacologyand toxicology → ACNP
ISSN journal
07428413
Volume
106
Issue
2
Year of publication
1993
Pages
495 - 501
Database
ISI
SICI code
0742-8413(1993)106:2<495:EOCADO>2.0.ZU;2-C
Abstract
1. The effect of chloride on serum angiotensin 1-converting enzyme (AC E) activity was characterized in eight mammalian species: dog, guinea pig, hamster, human, mouse, rabbit, rat, and sheep. 2. Optimum chlorid e concentrations varied from 300 mM for rabbit to 1700 mM for hamster. 3. The increments with these optimum concentrations with respect to 1 00 mM chloride concentration were from 1.4-fold in rabbit to 7.9-fold in hamster and dog. 4. There was no correlation between serum chloride concentration or serum ACE activity and optimum chloride concentratio n. 5. Serum ACE increased only in humans with diamide pretreatment sug gesting the presence of endogenous inhibitors.