INTEGRIN-MEDIATED SIGNALING OF GELATINASE-B SECRETION IN COLON-CANCERCELLS

The progression of colon cancer has been linked to both cell adhesion molecules called integrins and matrix-degrading enzymes called metallo proteinases. Herein we report that the alpha v beta 6 integrin express ed in colon cancer cells induces gelatinase B secretion through the C- terminal cytoplasmic extension unique to the beta 6 integrin subunit, and that this ligand-independent event involves activation of the prot ein-kinase-C pathway. (C) 1998 Academic Press.