CHROMOSOME-ABNORMALITIES IN PERIPHERAL-BLOOD LYMPHOCYTES FROM MACACA-FASCICULARIS AND ERYTHROCEBUS-PATAS (CERCOPITHECIDAE, CATARRHINI) AFTER X-RAY-IRRADIATION

In this paper, we describe the results of a qualitative and quantitati ve study of chromosomal reorganizations in X-irradiated (1 Gy and 2 Gy ) lymphocytes from Macaca fascicularis (MFA) and Erythrocebus patas (E PA). A total of 515 breakpoints in M. fascicularis and 271 breakpoints in E. patas have been detected, identified and localized in the ideog ram of the species. The Chi square test indicates that the distributio n of breakpoints along the chromosomes is not random in M. fasciculari s, and is not random for the p and q arms and bands in both species. C hromosome 5 of M. fascicularis (MFA5), chromosome 1 of E. patas (EPA1) , and chromosome arms MFA5q, and EPA Ip are significantly more affecte d than expected, while chromosome MFA9 is less affected. Terminal regi ons of chromosome arms accumulate a higher number of breakpoints than the rest of the chromosome (44.4% in M. fascicularis and 45.98% in E. patas); 92.06% and 91.97% of breakpoints are observed in G negative ba nds in M. fascicularis and E. patas, respectively. (C) 1998 Elsevier S cience B.V. All rights reserved.